Serotonin reverts age-related capillarization and failure of regeneration in the liver through a VEGF-dependent pathway
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چکیده
منابع مشابه
Serotonin reverts age-related capillarization and failure of regeneration in the liver through a VEGF-dependent pathway.
The function of the liver is well-preserved during the aging process, although some evidence suggests that liver regeneration might be impaired with advanced age. We observed a decreased ability of the liver to restore normal volume after partial hepatectomy in elderly mice, and we identified a pathway that rescued regeneration and was triggered by serotonin. 2,5-dimethoxy-4-iodoamphetamine (DO...
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ژورنال
عنوان ژورنال: Proceedings of the National Academy of Sciences
سال: 2011
ISSN: 0027-8424,1091-6490
DOI: 10.1073/pnas.1012531108